Hello friend, the truth is a great question. I don't have VR to be able to test it, there are people who have told me that VR doesn't detect reshade, another that depends on VR. But in my opinion I think that to date no one has confirmed it to me and on YouTube I have not seen anyone upload a video showing a reshade in vr. Now that if what I have managed to find on the internet is a person who has created a universal vr filter for reshade that simulates as if you were wearing glasses. I guess we'll have to wait a while for the vr to advance so they can detect the reshade.