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Not sure whether to release this one or not.

It's a novel project, but there is an indication that some people may have an anaphylactic reaction to sodium fluorescein.

https://youtu.be/Gxk9aHXUiow

It's commonly injected into people's blood as a tracer dye to make veins at the back of the eye more visible, and that seems to be where the main hazard is.  But there's also a suggestion that ingesting it or making contact with it can also cause issues.

That said, other food colourings can also cause anaphylactic shock, notably E110 sunset yellow, which is one of the most common food colourings, carmine E120, annatto E160b, allura red E129 and many others.  So it's possible that as a low quantity food colourant sodium fluorescein poses no greater risk.

The fact it doesn't have an E-number suggests it's not been approved for use in food, which may be down to a lack of proper testing in that situation.  Possibly originating from the scare stories from the medical industry where a reaction was triggered by pumping high doses into people's blood!  (Something that is not normally done with other food colourings!)

Not sure whether to release this one or not.

Comments

I have a bad reaction to you NOT doing stuff like this, so...you know...keep it up!

Michael Thompson

Are there any low voltage solutions for a fog machine? I would like one in my car, but i know normal ones require a decent amount of power.

Elliott Krimchansky

We use it to check the route waste water sewage takes in the sewage system. Sometimes you don’t no where the tubes go and the we check it with a bucket water and some green stuff we call it. And when we got a new on the job they put always way to much in the bucket. We have a case where the dye water make contact with a creek and half hour later the telephone going crazy with people worrying that something was very wrong.

I built one for my Uranium Glass BonBon dish with silver stand ( a quid from a local charity shop!) I used Ultrabright uv 3mm diodes from Bright Components with a 75 ohm resistor per two led's- just on a flat bit of scrap perf board-it works a treat, running off a £2 charger from Poundland - they are great value for money as you can run two projects off one plug! (2 amp MAX output - so at 1- 1.2 amps no probs !)

Mike Hughes

Spoof video of Radium gin. I really like that idea. Your right people would go crazy searching for it.

Alex Taylor

I love it! Yes I like the idea of a lit base for it. Not ferociously bright, but enough to highlight it.

Michael Thompson

Definitely time to make a UV base for the bottle.

It's very effective. For small water features polymer gel crystals also have an interesting effect.

Big Clive

I may or may not have done that somewhere....

Big Clive

Ha ha ha ha, brilliant! So good you can't publish it. :( Perhaps as Palerider1942 says, reshoot is as making a "prop" and decorate the bottle with a skull and crossbones.

Graeme Hart

I don't personally think this is dangerous, but you can never tell with Youtube these days

Anonymous

Didn't I say fluorescein was fun? Next step: a 3D printed stick-on base for a Poundland glass, containing a UV led and 2032. Glowing drink to the dregs, without having to point your torch at it.

This would be perfect blinker fluid for chrisfix!

Andreas Dorfer

this is perfectly fine for repairing the spirit level in a carpenter level. Things might dry out and then you need to replace the fluid.

Andreas Dorfer

if you rerecord the intro and say that you are making this as a "prop" for parties and such, later on you could mention that for the most part it is non toxic if some numpty happened to take a swig however it has been known to cause reactions in a select few so probably best not.

Palerider1942

I don't see why you shouldn't publish this video?! It's very educational. I didn't even know about this dye. Now I do, thanks to you and your video.

MarkM

This gives me naughty ideas for public water features :^)

Jesse_Fish_45

It looks delicious, but I don't have any gin or dye, so I will stick to the dark and stormy- I am of the opinion that some numpties out there may take you to task if you release it to the masses. By the way, thanks for putting the gerber files up, just ordered some from jlcpcb $7 with shipping!! brilliant- it not worth the hassle of making them when they are this cheap.

Mike Hughes

Awwww, what a thaught, pink or green flourescent dye in the fountain, sounds wonderful. It would piss a lot of people off I bet. :)

Technically speaking I do have a second channel. BigCliveLive

Big Clive

Yeah, chances are you're gonna get a community strike just from the safety nellies, best leave it unlisted

Jrandom Bob

I thought putting Mr Bubble in the town square fountain looked like fun, radioactive bubbles sound even better.

Jim

That looks very Radium like (As far as I know) I had that dye put in my eyes at the national neuro hospital a while back, I don't remember it stinging and no nasty reaction, thank goodness. If I could drink alcahol, I would make some of that, I love the look of it. :)

Cool! If I drink enough of that radioactive gin, I probably will save a lot on electricity, as I will not need lights at night.

Rocco Rizzo

I say don't BUT - The "alcohol" is more dangerous than the dye. ;-// I used to use this dye in the 1980s for it intended purpose of checking drainage in a large old factory, I was a plant draughtsman after my engineering apprenticeship. Interesting memories from back then when things and techniques changed slower than today. One of the strange things about "Gothic Works" Main Gas works in Padiham Lancs was they changed the river Calder course. in the late 1950s causing confusing drainage for me.

John Harrison

I haven't watched it yet but I say hold off for now if it causes concern see how you feel about it tomorrow

Michael Thompson

Not yet watched as I write Clive but will do, but could be a tricky one in the current climate. I'd stick with just to us Patreons but if you do, slap disclaimers all over it, make it a spoof, the lot. Someone will still be offended by it however you go.

Keith Pawson

Not approved by the FDA? Well, neither have some naturally occurring compounds found in fruit. But, that is the same organisation that approves of small quantities of RAT POISON in cereals!

Andrew Donaldson

It's a fascinating video Clive and a beautiful result. But like others say, perhaps release it as a spoof video, saying that it is actual Radium you are putting in there, something people are unlikely to obtain. Otherwise, people will be drinking the stuff and then complaining when they have a bad reaction!

Dr Andy Hill

If you had pitched the video as an instructable on making a prop that would be fine, that's what most would use it for anyway. As a foodstuff video it's definitely questionable and will almost certainly be demonetised. Record a new intro saying it's for prop use only?

The Tinkering Shed

It seems to be time for a "bigclovedotcom2" channel where you can put all those questionable stuff on it. It would be a shame if public could not see it, and by using the 2nd channel you would protect your main income source from being flagged for demonetiting and such...I would not put it on the main channel.

Peter Stimpel

I would keep it private it’s just gonna get demonetized or flagged.

Lostngone

So... Pretty much the same as any other compound listed in that database...

Scott Miller

Disclaimer: Anything BigClive does poses a serious risk of injury, death or enlightenment. Do not attempt to replicate BigClives actions at home. (Also, If you live in California, you will die of cancer before BigClives antics can harm you.)

Scott Miller

Don't see why you're so worried. If the stuff can be injected directly into a vein, swallowing a wee bit is hardly going to kill you. Anaphylactic shock is nothing to sneeze at, but the list of things that can cause it in susceptible individuals is pretty long and commonplace. Peanuts, eggs, dairy, shrimp, bee stings, etc.

Paul Ste. Marie

I'd keep it here and not post it on the public channel.

The dye I used on my beard had prominent warnings about not using if henna had been used in the past.

Big Clive

Official Information from the National Poisons Database..Toxicity At the time of writing, little information on the toxicity of fluorescein was available. Anaphylaxis has been reported following topical application to the eye, ingestion and injection. Extravasation can result in severe local tissue damage due the high pH of fluorescein solution for injection. Features Unlikely to occur following topical application of eye drops or ingestion. Adverse effects after therapeutic intravenous use include: GI upset, skin rashes, and syncope. Rarely more severe reactions may occur including hypotension, jaundice, chest pain, tachyarrhythmias, convulsions and cardiac arrest. Skin, urine and soft contact lenses may be stained yellow. Skin discolouration usually disappears within 6 to 12 hours, and urine typically returns to its normal colour within 36 hours.

Here is the official information from the National Poisons Database

In retrospect, as funny as it may be, perhaps It may be worth making it as more of a spoof video, perhaps suggesting adding Radium to your gin, something people can't actually buy. See how many people you can get searching eBay for something obscure like the Scottish MRE heater :D

I should never have mentioned the rhodamine B. People will discover for themselves that I wasn't kidding. It's the most extreme dye experience ever. The tiniest speck of dust explodes into pink on contact with water.

Big Clive

It had no obvious effect at all when I drank it on the live stream.

Big Clive

I can recall going for a routine medical thing and they just injected a small amount of saline solution to purge the anaesthetic line and I suddenly felt so nauseous. It seems any disturbance in the blood can have that effect.

Big Clive

I could play safe and call the video "Anaphylactic diarrhea gin".

Big Clive

I can see it getting stomped on by YT for just the Rad ium word. I'd pass on publishing it. Don't get me wrong, it's great! I like it!

Nani Isobel

Diskosharts?

William Nimmo

Im Not a Doctor & I dont play one on TV, but I am intreeeged with them colors But have the sense not to Buy em or mess with them Ill stick to Discosharts and Yeager

William Nimmo

I'm in two minds about this. Getting a shock from the hotdogger forks is more than surviveable but getting an anaphylactic shock and not having an epi-pen nearby is dodgy. Despite warnings, people are people and some will do these things just for fun. In saying that, I think I'd be more worried about people getting hold of Rhodamine B.......can just imagine the amout of people that ordered it on the back of the live stream. And in a week or two the world will be pink :D :D I've never had to be given Sodium Fluorescein but have had to be injected with Gadolinium for quite a few MRIs. I did have mild side effects.......coldness running up my arm from the injection site but that's quite common.

John Carr

So, BC, we gotta know: how long did (? will) the decanted portion last, and did it make you nauseous or perceive colors (or colours) differently?

I have this reaction. I found out at an eye appointment where they were doing a check of the blood vessels in the back of my eyes. They told me at the time that 5% of males get a nausea reaction after a few minutes of injection. Boy were they correct. It only lasted about 2 minutes, and I didn't actually vomit, but I had to stick my face in a bucket the whole time which they had on hand, so it apparently happens often enough if you do these test all the time. Obviously mine is a single datapoint about injected Fluorescein, but while I wouldn't try it myself I feel like your warning was probably sufficient. Also here's a report from the U.S. National Institutes of Health (a proper government department) that basically says that injections can lead to rare bad reactions but otherwise seemingly safe. But always read for yourselves: https://pubmed.ncbi.nlm.nih.gov/16827689/

Ken Kopin

Oh and put a even bigger one in the description.

Maybe just start and end with a huge disclaimer.

Wow! That's bright! Has there actually been any recorded cases of sodium fluorescein causing injury? I would say the gin itself is more of a risk to life and limb than the tiny amount of dye, but then I am not a doctor!

The dye in black hair dye being a good example. People who get black henna tattoos which contain much higher concentrations than are allowed causes a sensitisation to the chemical, which can in future make people allergic to things. Bodies are odd. Since I am actually a healthcare person, I think I might need to add the disclaimer, that this is to the best of my knowledge and should not be used as official medical advice!

Thing is Clive, ANYTHING, literally anything can cause Anaphylaxis in some people. Ultimately Anaphylaxis is the bodies immune system reacting out of proportion and going haywire. Being exposed to any chemical or substance natural or otherwise could be that thing for people. So whilst yes, it could indeed cause anaphylaxis, though I suspect not much more likely than anything else.


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